Kryptman

Kryptman is an Inquisitor (well, ex-Inquisitor) of the Ordo Xenos who has dealt extensively with the Tyranids. He was not the first human to have contact with them, but he was the first to identify and name them when he investigated the loss of contact with the Tyran research station after its destruction by Hive Fleet Behemoth. He also roused the Imperium to take a stand against the threat.

As the Tyrannic Wars continued, Kryptman became one of the foremost researchers into means of halting the Tyranid advance, but his determination to end the threat consumed him, and he came up with a couple of ideas that even his fellow Inquisitors thought were too crazy to implement.

First, he created a cordon by committing Exterminatus on a "moat" of worlds in the path of Hive Fleet Leviathan. The idea was that, as Tyranids tried to get through the cordon, they would starve to death. It did slow Leviathan's advance, but the loss of a dozen planets on one Inquisitor's say-so was too much for the rest of the Inquisition. They told him to cut it out and expelled him from the Inquisition, but he was far enough away that he could not actually be arrested.

When he couldn't get anyone to buy in on the cordon plan, Kryptman decided that if the Tyranids could not be destroyed, they could be used, so he used some Genestealers captured during the course of the Exterminatus campaign to lure a splinter fleet into an Ork empire. Unfortunately, not only did the Tyranids fail to wipe out the Orks, and the Orks fail to wipe out the Tyranids, leading to the Octarius War.

In the end, as more and more Hive Fleets entered the Imperium, Kryptman's cordon idea started to look better and better to the authorities, but Leviathan's attack from underneath the galactic plane proved that such a cordon would have to surround the galaxy in all three dimensions, which might be more than the Imperium could bear.