Vampire: The Requiem

Vampire: The Requiem is the flagship title of White Wolf's New World of Darkness line, and, as its name suggests, the equivalent of Vampire: The Masquerade. The changes are as follows:

• 13 Clans with fleshed out, restricting histories become 5 archetypes with vague, open-ended histories. Naturally, both oWoD and nWoD fans believe their way to be the true way, not realising that they are both enormous faggots for playing WoD in the first place.
• The Camarilla becomes 5 Covenants with mutually exclusive goals.
• The Sabbat becomes VII
• The Infernalists become the more sporadic, less-organized Belial's Brood.
• Arguably the biggest difference is that you can't just make someone a Vampire by draining them and feeding them your blood, now you have to spend a dot of Willpower.

There are all sorts of splats and expansions, including one for playing in the Roman Empire, one for various other historical settings (WW1 to Ancient Egypt), one for playing as a ghoul and one for the eighties (I am deadly serious).