Sphere of Annihilation
An error in the fabric of space, the Sphere of Annihilation is not actually a sphere so much as a missing piece of reality that just so happens to look like a sphere. Anything that touches it is destroyed -- no ashes, no dust, no soul, no afterlife, just GONE. How this destroys whole people and not just the parts that touch, while simultaneously destroying only pieces of ground but not the entire continent at once, we do not know.
Up until 4th Edition, this item was the ultimate "no, fuck YOU!" weapon or trap that DMs would use against player characters, ones that were getting too cocky about having more hit-points than God and being able to survive 20d6 fireballs. Appropriately, it is one of the traps in the Tomb of Horrors.
History
In Advanced Dungeons and Dragons, it was a miscellaneous magic item which means you could find it by chance in some dragon's hoard -- if it didn't kill you when you accidentally brushed your hand over it. Magic-Users could move it with the power of their big throbbing brains, and threaten monsters with a black hole two feet in diameter (in 1st Edition Advanced Dungeons & Dragons) that moved about 1 foot per round. The Talisman of the Sphere, a magic item that helps with controlling the Sphere, doubles this movement rate, which D&D v3 also uses. In D&D v3, it was 2 feet in diameter, anyone could move it at 10 feet per round with a DC30 check adding your level & Int modifier (doubled if you had the sphere's accompanying talisman).
In BECMI Dungeons & Dragons, they were quasi-creatures named 'blackballs'. Blackballs are about 5 feet in diameter, and were one of the few things that Immortals would stay the hell away from. They destroy anything they touch, and act like creatures but never communicate. No Immortal who was vacuumed up by one was ever seen again. In theory, they're tools or probes from beyond the barrier that keeps the multiverse at only five dimensions, and are sent out to collect items for examination by the barrier-makers.
The 3.0 Ed. Epic Level Handbook altered the above 'blackballs' into the far more awesome sounding Umbral Blots, theorized to be the creation of some long lost pantheon of gods. Presumably they were 'lost' because they looked at the Sphere, decided "You know what this needs? The ability to CHASE you" and promptly ate shit.
While separated from its mind, the body of the Elder Evil Pandorym resembles a larger-than-normal Sphere of Annihilation that always moves towards anyone that tries to control it; any relation between this form and umbral blots is unknown.
In 4e, it's a standard level 29 trap that does 6d6+10 with 15 ongoing damage, a nerf which to some is but a small part of why 4e should Die In a Fire™.
In 5e, the sphere deals a modest amount of Force damage rather than destroying something outright unless the object is small enough to be completely engulfed, in accordance with 5th's move away from true "save or die" effects. The sphere is also much, much easier to move about with power of your mind, going five times your Int mod on a successful check.
In Pathfinder, the Spheres of Annihilation are the waste generated by the technomagic generators found in the only hive city in the full of undead planet Eox, the Halls of the Living.
The Sphere of Annihilation also exists as a spell in the old, miniature roguelike Larn, where it flies away from the caster, annihilating what it passes over, and bounces off the edges of the dungeon. If you cast two and they collide, they annihilate each other and everything in a fair-sized circle around them. Even casting just one can easily erase some critical item and make the game unwinnable.