Desperate Gods
Desperate Gods claims to be an open source board game built with Unity, but it's actually a perfect complete tabletop simulator created by accident. The game is designed to use absolutely no automation; players use the mouse and keyboard commands to pick up and roll physical dice, draw, flip, and rotate cards, move their game pieces, and even enforce the rules, all manually.
This program has enormous potential for online role playing and wargames, and it seems to be more complete than DERP.