Maztica
One of the three off-shoot campaign settings to Forgotten Realms, alongside Kara-Tur and Al-Qadim. Like its counterparts, it focuses on an "ethnically different" area of the Toril world - in this specific case, a South America expy, in contrast to the Arabic Al-Qadim and the "Oriental" Kara-Tur.
Noted for being pretty well researched, for the time, but quite shamelessly ripped wholesale from the actual lore and history of South America, complete with the invasion of Conquistador-expies (a Helm-worshipping legion of mercenaries) who commit such brutal atrocities against the natives that Helm has to found a whole new Paladin order to try and make up for the shit they did.