Trinity

The Trinity Continuum, once known as the Aeon Continuum before trademark infringements got called up and forced the name change, is a set of three interlinked settings done by White Wolf early into its life, after its Old World of Darkness meta-setting took off.

A meta-setting divided into three, each based on different parts of humanity's "life cycle" and released going backwards - so from the oldest point to the earliest. Got cancelled whilst it was only partly developed, but there are rumors of a rewrite coming up in the late 2010s...

Aeon/Trinity

The namesake setting, a post-apocalyptic Earth in which an incredibly advanced human civilisation was devasted when the Aberrants, mutant super-humans enhanced with qantum-manipulating powers, turned on humanity and destroyed it in the Aeon War. Human players are psychics, awakened with specialised technology to destroy the remaining Aberrants and help fully restore humanity. Also, there's a metaplot about a coming alien invasion.

Aberrant

Humanity during the "Golden Age" before the Aeon War. Quantum-empowered superhumans called Novas have begun to arise and are seemingly leading humanity towards a new future. Since Trinity came first, you know what's really going to happen, right? The Novas who really mutate are called "Aberrants", after all. Essentially a grimdark superhero RPG.

White Wolf at this time was notorious for its writers having issues, which tended to creep into the metaplot, and Aberrant was a particularly bad example. Remember that the chief writer-guy was a rather disgruntled gay man, and then take a look at how many of the gay male novas tend to be the powerhouses, and how the heteronormative NPCs tend to be dumb, ugly creeps. Hell, let's look at the fact that the setting's Magneto expy, Divis Mal, is gay, the most powerful Nova in the world, an elightened visionary, and pretty much completely and utterly right, since it's humanity who starts the Aeon War by secretly sterilizing Novas en-masse, provoking them into attacking to defend themselves.

Adventure!

The final setting released and the earliest on the point. Glorious pulp age misadventures with talking gorillas, lost cities, Nazi superweapons, twofisted gadgeteers and all that good stuff. .