Werewolf: The Forsaken
The New World of Darkness analogue to Werewolf: The Apocalypse. Dumps the bloody-minded eco-hippies metaplot for a much vaguer "border patrol on the shores of Animistic Hell" setting.
Backstory
In the ancient past, the worlds of Flesh and Spirit were one, creating a world/time called Pangaea. In this time, the mighty wolf-spirit Father Wolf kept the peace between humans and spirits, destroying either of those that got out of line. The moon-spirit, Mother Luna, became enamored with Father Wolf's strength and lay with him, giving birth to the first werewolves, who helped their father in his quest. But as Father Wolf battled terrible demon-gods, his strength began to wane, and the world began to sicken, for he could no longer do his duty.
Following their lupine instincts, most of these first werewolves rose up to challenge their father to step down as leader of the pack; unable to stand down by his nature, they were forced to slay him. His death howl tore Pangaea apart, shattering it into the worlds of Flesh and Spirit. A grieving Luna cursed her children with weakness to her sacred metal, silver, and charged them to take up their father's mantle. This they have done ever since.
Werewolves and You
In contrast to their predecessor in the Old World of Darkness, all werewolves are the result of werewolf on human sex; werewolves mating together is a Harmony-shattering event that can spawn evil, werewolf-hating demons called Unihar, and werewolves don't mate with wolves (but, if they must, all that happens is a litter of normal wolf pups - you sicko!), for all that the Pure have their legends of a wolfborn werewolf Messiah.
As beings possessed of dual natures -wolf and man, as well as spirit and mortal- their morality replacement is Harmony, which represents how well they can strike a balance between the two aspects of their existence.
Most human/werewolf matings produce wolfblooded, which are basically the game's equivalent to kinsfolk; they're more resistant to Lunacy and that's about it.
Werewolves have five forms; human, wolf, near-human, near-wolf and "warform" (Garou, a humanoid wolf mixed with a walking murder-machine that is prone to going into Death Rage and trying to kill everyone around it). There's also a high-level power called Primal Form, which adds a "dire wolf" form that is... well, picture a wolf big enough to eat a human in one bite, and you got the idea.
Werewolves are protected by Lunacy, which drives humans mad with fear and blurs their memories if they survive the encounter.
Spirits, Pure and Hosts
These are the three threats a werewolf will most likely face off against in its (nasty, brutish and short) life.
Spirits are everywhere. They define and promote aspects of existence and do so to monomaniacal fixation; they are NOT good guys, and even spirits of things like Joy or Love are dangerous if they're left to their own devices.
Hosts are the shattered shards of the demon-gods that Father Wolf slew, which mostly exist as roving swarms of creepy-crawlies. Until they get strong enough that they can gnaw their way into peoples' living bodies and absorb their flesh to become grotesque half-human half-beasts. The two main ones are the Azlu (giant fucking brain-eating spiders) and the Beshilu (plague-spreading rats).
The Pure are werewolves who claim they're innocent of murdering Father Wolf, and so they hate Mother Luna for demanding they take his role and hate the Forsaken even more for taking Pangaea away from them. They reject Mother Luna, which among other things means silver hurts them worse, and they want to tear down the Gauntlet between worlds so the spirits can take over, hoping that this will restore Pangaea and allow them to become rulers. Thing is, there's a lot more of these bastards than there are of the Forsaken (that is, the good guys), and the spirits like them more since they don't try to boss the spirits around.
Other Shifters
A lot less focused on in this setting, but still present. There were two excellent books - Skinthieves, for "humans who change shape through magic" and "spirit-melded shifters" types and War Against The Pure for more "mythical shapechanger" types.
There's also the absolute atrocity known as Changing Breeds, which is basically every single fucking awful thing about Werewolf: The Apocalypse wrapped up in one shittastic package. Don't believe us? Take a look at this poor sap, who dared to try and dissect its awfulness chapter by chapter - he never managed to even finish it. http://destroythis.blogspot.com.au/search?updated-max=2014-07-31T18:46:00-07:00&max-results=7&start=7&by-date=false&m=1
Needless to say, nobody talks about Changing Breeds.