Ogryn

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Back in the days before Slaanesh, humanity had whole planets dedicated to housing criminals, a fair number of them were barely habitable heavy gravity worlds for some reason. Then the fucking Eldar gave birth to Slaanesh and society fell apart and these prisons were left isolated. The convicts then got out and proceeded to go nuts in orgies of violence and sex. For the next few thousand years these louts ate food and drank water and moonshine with large amounts of mercury and lead in them, were subject to unhealthy doses of radiation, engaged in plenty of incest and leadership was determined by who was the best at beating others with lead pipes. By the time the Emperor, there were dozens of planets full of large, durable and strong three meter tall dudes called Ogryns.

Though the Imperium of Man typically destroyed anything too divergent from the human form, the Ogryns DNA was stable enough to classify as a new evolution. The Imperial Guard has been using Ogryns as heavy shock troopers for millennia, helped by the Ogryns massive strength, iron-hard loyalty to the Emperor, and literal mindedness. Particularly intelligent Ogryns are given genetic enhancements called Bio Ogryn Neural Enhancement (BONE) and become BONE'EADs, effectively sergeants of squads who are even smarter (though they can only count on their hand with their thumbs making them confused).